Hybrids are a cross-breed of two or more different supernatural species. The term is commonly used to describe a werewolf turned into a vampire due to the fact that they were the first supernatural hybrid to be introduced in the series. However, since the werewolf-vampire hybrid's creation, there have been other cross-breed hybrids revealed in the series' universe, such as Siphoner turned witch-vampire hybrids, werewolf-witch hybrids, and, in the rare case of Hope Mikaelson, a witch-werewolf-vampire tribrid.

Known kind of hybrid: