Her brother is the late Vittorio De Angelis, who voiced Joey Tribbiani in the Italian version of the show. She is also the daughter of the late voice actor Manlio De Angelis, the granddaughter of voice actor Gualtiero De Angelis, the niece of singer Enrico De Angelis and the cousin of voice actor Massimiliano Virgilii.
De Angelis is best known for having dubbed such actresses such as Jennifer Aniston, Cameron Diaz, Angelina Jolie, Sarah Michelle Gellar, Jordana Brewster and Halle Berry. She dubbed over the voices of Mia Toretto in the Fast and the Furious film series, Wendy Testaburger in South Park, Natalie Cook in the Charlie's Angels film series and Elizabeth Burke in White Collar. In a 2015 interview, she stated that the actress she prefers to dub is Jennifer Aniston.
De Angelis and her husband, Massimiliano Torsani took part in the creation of an app which allows someone to listen to and identify the voice of an Italian dub actor.