- Saj
- Sally
- Sam Anderson
- Sam McMurray
- Sam Pancake
- Sam Seder
- Sam Simon
- Samantha Smith
- Sandra Gould
- Sandra Greene
- Sandra Greene's father
- Sandy
- Sara
- Sarah
- Sarah Ferguson
- Sarah MacDonnell
- Sarah Murdoch
- Sarah Peterson
- Sarah Tuttle
- Sasha Alexander
- Schnoodle
- Science Boy
- Scott Adsit
- Scott Mosenson
- Scott Paetty
- Scott Richards
- Scott Silveri
- Sean Corvelle
- Sean Penn
- Sean Whalen
- Season 1
- Season 10
- Season 1 (Joey)
- Season 2
- Season 2 (Joey)
- Season 3
- Season 4
- Season 5
- Season 6
- Season 7
- Season 8
- Season 9
- Sebastian Jones
- Selma Blair
- Sergei
- Seth Kurland
- Seventh Friend
- Sex Toy Story 2
- Shana Goldberg-Meehan
- Shane Keller
- Shane Nickerson
- Sharon Majeski
- Shashi Bhatia
- Shawn Christian
- Sheldon Epps
- Sheldon Twins
- Shelley Berman
- Shelley Jensen
- Shelly
- Sherilyn Fenn
- Sherri Shepherd
- Sherry Bilsing
- Shovelly Joe
- Sid Goralnik
- Sidney Marks
- Sierra Dawn Hill
- Silvercup Studios
- Silvia
- Simon Harvey
- Simone Mori
- Smelly Cat
- Soap Opera Party
- Sofia Milos
- Soleil Moon Frye
- Sonya
- Sophie
- Spoiler
- Stacy Galina
- Stan Kirsch
- Stan Sellers
- Steffani Brass
- Stephanie
- Stephanie Dicker
- Stephen Kearney
- Stephen Prime
- Stephen Samuels
- Stephen Waltham
- Stephon Fuller
- Steve
- Steve (Chandler's boss)
- Steve (drug addict)
- Steve Cera
- Steve Hytner
- Steve Ireland
- Steve Park
- Steve Pierce
- Steve Susskind
- Steve Zahn
- Steve Zuckerman
- Steven Eckholdt
- Steven Fisher
- Steven Harad
- Stevens siblings' father
- Stevens siblings' mother
- Stryker Ramoray
- Stu
- Stuart
- Stuart Fratkin
- Super-Sized Episodes
- Susan Bunch
- Susan Sarandon
- Susan Ward
- Susan Yeagley
- Susie
- Susie (mouse)
- Susie Moss
- Susie Park
- Suzanna Voltaire
- Suzanne Lanza
- Suzie V. Freeman
- Symba Smith
- T.J. Thyne
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